Ejercicio de alta intensidad en pacientes con cáncer. Una revisión bibliográfica
DOI:
https://doi.org/10.59856/arch.soc.chil.med.deporte.v61i1.17Palabras clave:
calidad-de- vida, ejercicio-aérobico, fatiga, fitness, neoplasia, cáncerResumen
El manejo en pacientes con cáncer de mama involucra combinaciones de tratamientos prolongados y agresivos en forma local o sistémica, causando efectos tóxicos y secundarios a corto y largo plazo, aumentando la morbilidad y el riesgo de mortalidad por causas no relacionadas al cáncer. Los principales efectos secundarios que reportan las pacientes son fatiga relacionada al cáncer, disminución en el fitness cardiorrespiratorio y disminución en la calidad de vida.
El ejercicio es una estrategia que desde hace décadas se utiliza para combatir los efectos secundarios producidos por los tratamientos antineoplásicos. Hasta ahora, las recomendaciones de ejercicio en pacientes con cáncer se enfocan principalmente a la actividad aeróbica de moderada intensidad, esto es debido a que en la práctica clínica y las guías basadas en la evidencia, el ejercicio, ha sido limitado por la intensidad básicamente por cuestiones de seguridad, sin embargo, la reciente evidencia acepta que el entrenamiento interválico a alta intensidad (HIIT) es seguro, factible y bien tolerado por esta población. Por otra parte, estudios de ejercicio a alta intensidad realizados en distintas enfermedades crónicas, incluyendo al cáncer, han demostrado mejoras en el fitness cardiorrespiratorio, disminución en la fatiga relacionada al cáncer y mejoras en la calidad de vida.
El objetivo de la siguiente revisión es abordar la importancia del ejercicio físico en el control de los efectos adversos de los tratamientos antineoplásicos en pacientes con cáncer de mama y profundizar en el entrenamiento de alta intensidad como modalidad segura y eficaz.
Referencias
Ministerio de Salud. Guia Clínica Cáncer de mama. Minsal [Internet]. 2010 [cited 2014 Aug 22]; Available from: http://scholar.google.com/scholar?hl=en&btnG=Search&q=intitle:No+Title#
Lakoski SG, Eves ND, Douglas PS, Jones LW. Exercise rehabilitation in patients with cancer. Nat Rev Clin Oncol [Internet]. Nature Publishing Group; 2012;9(5):288–96. Available from: http://dx.doi.org/10.1038/nrclinonc.2012.27
Dolan LB, Campbell K, Gelmon K, Neil-Sztramko S, Holmes D, McKenzie DC. Interval versus continuous aerobic exercise training in breast cancer survivors—a pilot RCT. Support Care Cancer [Internet]. 2015; Available from: http://link.springer.com/10.1007/s00520-015-2749-y
Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, Galvão D a, Pinto BM, et al. American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc [Internet]. 2010 Jul [cited 2014 Aug 18];42(7):1409–26. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20559064
Itriago L, Cortes G, Silva N. Cáncer en Chile y el mundo : una mirada epidemiológica , presente y futuro. Rev Med Clin Condes. 2013;24(4):531–52.
Prieto M. Epidemiología del cáncer de mama en Chile Epidemiology of breast cancer in Chile. Rev Med Clin Condes. 2011;22(4):428–35.
Ministerio de Salud. Guia clinica cancer de mama en personas de 15 años y mas 2005. Minsal. 2005;1–43
Courneya KS, Vallance JK, Culos-Reed S, McNeely ML, Bell GJ, Mackey JR, et al. The Alberta moving beyond breast cancer (AMBER) cohort study: a prospective study of physical activity and health-related fitness in breast cancer survivors. BMC Cancer [Internet]. BMC Cancer; 2012;12(1):525. Available from: http://www.biomedcentral.com/1471-2407/12/525
McNeely ML, Campbell KL, Rowe BH, Klassen TP, Mackey JR, Courneya KS. Effects of exercise on breast cancer patients and survivors: a systematic review and meta-analysis. CMAJ. 2006;175(1):34–41.
Battaglini CL, Mills RC, Phillips BL, Lee JT, Story CE, Nascimento MGB, et al. Twenty-five years of research on the effects of exercise training in breast cancer survivors: A systematic review of the literatura. World J Clin Oncol. 2014;5(2):177–91.
Gillespie HS, Mcgann CJ, Wilson BD. Noninvasive Diagnosis of Chemotherapy Related Cardiotoxicity. Curr Cardiol Rev. 2011;234–44.
Mann DL, Krone RJ. Cardiac disease in cancer patients: an overview. Prog Cardiovasc Dis [Internet]. 2010 [cited 2014 Dec 20];53(2):80–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20728694
Ryan JL, Carroll JK, Ryan EP, Mustian KM, Fiscella K, Morrow GR. Mechanisms of cancer-related fatigue. Oncologist. 2007;12 Suppl 1(suppl 1):22–34.
NCCN NCCNGV 1. 201. PMC-R. NCCN Clinical Practice Guidelines in Oncology. Cancer-Related Fatigue [Internet]. National Comprehensive Cancer Network 2015 p. 1–53. Available from: www.nccn.org/professionals/physician_gls/f_guidelines. asp#fatigue
Portenoy RK, Itri LM. Cancer-related fatigue: guidelines for evaluation and management. Oncologist. 1999;4(1):1–10.
Hofman M, Ryan JL, Figueroa-Moseley CD, Jean-Pierre P, Morrow GR. Cancer-related fatigue: the scale of the problem. Oncologist. 2007;12(1):4–10.
Mcneely ML, Courneya KS. Exercise and Cancer-Related Fatigue Syndrome. Exercise and Cancer Survivorship. 2010. p. 17–37.
Cramp F, Byron-Daniel J. Exercise for the management of cancer-related fatigue in adults. Cochrane Libr. 2012;(11):1–84.
Mustiam KM, Sprod L, Janelsims M, Jeppone L, Supriya M. Exercise Recommendations for Cancer-Related Fatigue, Cpognitive Impariment, Sleep pronlems, Depression, Pain, Anxiety, and Physycal Dysdfunciton: A Review. Oncol Hematol Rev. 2013;8(2):81–8.
Gilliam L a a, St Clair DK. Chemotherapy-induced weakness and fatigue in skeletal muscle: the role of oxidative stress. Antioxid Redox Signal [Internet]. 2011 Nov 1 [cited 2014 Aug 22];15(9):2543–63. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3176345&tool=pmcentrez&rendertype=abstract
Tian L, Lu HJ, Lin L, Hu Y. Effects of aerobic exercise on cancer-related fatigue : a meta-analysis of randomized controlled trials. Support Care Cancer. 2015;(305).
Bower JE, Bak K, Berger A, Breitbart W, Escalante CP, Ganz P a, et al. Screening, assessment, and management of fatigue in adult survivors of cancer: an American Society of Clinical oncology clinical practice guideline adaptation. J Clin Oncol [Internet]. 2014;32(17):1840–50. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24733803
Saligan LN, Olson K, Filler K, Larkin D, Cramp F, Sriram Y, et al. The biology of cancer-related fatigue: a review of the literature. Support Care Cancer [Internet]. 2015; Available from: http://link.springer.com/10.1007/s00520-015-2763-0
Meneses-Echávez J, González-Jiménez E, Ramírez-Vélez R. Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis. BMC Cancer [Internet]. 2015;15(1):77. Available from: http://www.biomedcentral.com/1471-2407/15/77
Meneses-Echávez JF, González-Jiménez E, Robinson R-V. Supervised exercise reduces cancer-related fatigue : a systematic review. J Physiotehrapy. 2015;61:3–9.
Martin E a, Battaglini CL, Hands B, Naumann F. Higher-Intensity Exercise Results in More Sustainable Improvements for VO. Oncol Nurs Forum. 2015;42(3):9.
Jones LW, Douglas PS, Eves ND, Marcom PK, Kraus WE, Herndon JE, et al. Rationale and design of the Exercise Intensity Trial (EXCITE): a randomized trial comparing the effects of moderate versus moderate to high-intensity aerobic training in women with operable breast cancer. BMC Cancer [Internet]. BioMed Central Ltd; 2010;10(1):531. Available from: http://www.biomedcentral.com/1471-2407/10/531
Velthuis MJ, May AM, Koppejan-Rensenbrink RA, Gijsen BCM, van Breda E, de Wit GA, et al. Physical Activity during Cancer Treatment (PACT) Study: design of a randomised clinical trial. BMC Cancer [Internet]. 2010 Jan;10:272. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2927992&tool=pmcentrez&rendertype=abstract
Klassen O, Schmidt ME, Scharhag-Rosenberger F, Sorkin M, Ulrich CM, Schneeweiss A, et al. Cardiorespiratory fitness in breast cancer patients undergoing adjuvant therapy. Acta Oncol [Internet]. 2014 May 16 [cited 2014 Sep 15];(February):1–10. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24837860
Peel AB, Thomas SM, Dittus K, Jones LW, Lakoski SG. Cardiorespiratory Fitness in Breast Cancer Patients : A Call for Normative Values. J Am Heart Assoc. 2014;1–9.
Peel JB, Sui X, Adams SA, Ph D, Hébert JR, Hardin JW, et al. A prospective study of cardiorespiratory fitness and breast cancer mortality. Med Sci Sport Exerc. 2013;41(4):742–8.
Courneya KS, McKenzie DC, Mackey JR, Gelmon K, Friedenreich CM, Yasui Y, et al. Effects of Exercise Dose and Type During Breast Cancer Chemotherapy: Multicenter Randomized Trial. JNCI J Natl Cancer Inst [Internet]. 2013;105(23):1821–32. Available from: http://jnci.oxfordjournals.org/cgi/doi/10.1093/jnci/djt297
Sanchez JM, Sierra JC, Martín-ortiz JD. Evaluación de calidad de vida en pacientes con cáncer: una revisión. Rev Colomb Psicol. 2005;(14):34–45.
Schwartzmann L. Calidad de vida relacionada con la salud: asectos conceptuales. Cienc y Enfermería. 2003;(2):9–21.
Irarrázaval ME, Rodríguez P, Fasce G, Silva FW, Waintrub H, Torres C, et al. Calidad de vida en cáncer de mama: validación del cuestionario BR23 en Chile. Rev Med Chil. 2013;141(1):723–34.
Superintendencia de Salud. Calidad de vida relacionada a la salud (HR-QoL en población general. 2005).
González-Fajardo J a., Martín-Pedrosa M, Mengibar Fuente L, Salvador Calvo R, Almaraz a., Vaquero C. Evaluación de la calidad de vida en pacientes con síndrome postrombótico. Rev Chil Cir. 2013;65(4):321–8.
Araya P, Yañez A. Evaluación de la calidad de vida de pacientes mastectomizadas, tratadas en el instituto nacional del cáncer entre los años 2003 y 2005. 2006.
Fernández-López JA, Fernández_Hidalgo M, Cieza A. Los conceptos de calidad de vida, salud y bienestar analizados desde la perspectiva de la clasificacion internacional del funcionamiento (CIF). Rev Esp Salud Pública. 2010;84:169–84.
Volaklis K a, Halle M, Tokmakidis SP. Exercise in the prevention and rehabilitation of breast cancer. Wien Klin Wochenschr [Internet]. 2013 Jun [cited 2014 Aug 22];125(11-12):297–301. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23653151
McTiernan A, Kooperberg C, White E, Wilcox S, Coates R, Adams-Campbell L, et al. Recreational Physical Activity and the Risk of Breast Cancer in Postmenopausal Women. JAMA. 2003;290(10):1331–6.
Dallal CM, Sullivan-Halley J, Ross RK, Wang Y, Deapen D, Horn-Ross PL, et al. Long-term recreational physical activity and risk of invasive and in situ breast cancer: the California teachers study. Arch Intern Med [Internet]. 2007;167(4):408–15. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17325304
Courneya KS, Friedenreich CM. Physical activity and cancer control. Semin Oncol Nurs [Internet]. 2007 Nov [cited 2014 Aug 22];23(4):242–52. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18022052
Courneya KS, Segal RJ, Mackey JR, Gelmon K, Reid RD, Friedenreich CM, et al. Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial. J Clin Oncol [Internet]. 2007 Oct 1 [cited 2014 Aug 13];25(28):4396–404. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17785708
Courneya KS, Segal RJ, Mackey JR, Gelmon K, Reid RD, Friedenreich CM, et al. Effects of Aerobic and Resistance Exercise in Breast Cancer Patients Receiving Adjuvant Chemotherapy: A Multicenter Randomized Controlled Trial. J Clin Oncol [Internet]. 2007;25(28):4396–404. Available from: http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2006.08.2024
Mutrie N, Campbell AM, Whyte F, McConnachie A, Emslie C, Lee L, et al. Benefits of supervised group exercise programme for women being treated for early stage breast cancer: pragmatic randomised controlled trial. BMJ. 2007;334:517.
Eyigor S, Kanyilmaz S. Exercise in patients coping with breast cancer: An overview. World J Clin Oncol [Internet]. 2014 Aug 10 [cited 2014 Aug 18];5(3):406–11. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4127611&tool=pmcentrez&rendertype=abstract
Wolin KY, Schwartz AL, Matthews CE, Courneya KS, Schmitz KH. Implementing the exercise guidelines for cancer survivors. J Support Oncol [Internet]. 2013;10(5):171–7. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3543866&tool=pmcentrez&rendertype=abstract
Olson EA, Mullen SP, Rogers LQ, Courneya KS, Verhulst S, Mcauley E. Meeting Physical Activity Guidelines in Rural Breast Cancer Survivors. Am J Heal Behav. 2014;38(6):890–9.
Gibala MJ, Jones AM. Physiological and Performance Adaptations to High-Intensity Interval Training. Nestle Nutr Inst Work Serv [Internet]. 2013;76:51–60. Available from: http://www.karger.com?doi=10.1159/000350256
Gibala MJ, Little JP, Macdonald MJ, Hawley J a. Physiological adaptations to low-volume, high-intensity interval training in health and disease. J Physiol [Internet]. 2012 Mar 1 [cited 2014 Jul 11];590(Pt 5):1077–84. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3381816&tool=pmcentrez&rendertype=abstract
Nytrøen K, Rustad L a, Aukrust P, Ueland T, Hallén J, Holm I, et al. High-intensity interval training improves peak oxygen uptake and muscular exercise capacity in heart transplant recipients. Am J Transplant [Internet]. 2012 Nov [cited 2014 Aug 25];12(11):3134–42. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22900793
Tjonna a E, Lee SJ, Rognmo O, Stolen TO, Bye a, Haram PM, et al. Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study. Circulation [Internet]. 2008;118:346–54. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18606913
Wisløff U, Ellingsen Ø, Kemi OJ. High-intensity interval training to maximize cardiac benefits of exercise training? Exerc Sport Sci Rev [Internet]. 2009 Jul [cited 2014 Aug 25];37(3):139–46. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19550205
Guiraud TNAGVMPJMBL. High-Intensity Interval Training in Cardiac Rehabilitation. Sport Med (SPORTS MED). 2012;42(7):587–605.
Courneya KS, McKenzie DC, Gelmon K, Mackey JR, Reid RD, Yasui Y, et al. A multicenter randomized trial of the effects of exercise dose and type on psychosocial distress in breast cancer patients undergoing chemotherapy. Cancer Epidemiol Biomarkers Prev [Internet]. 2014 May [cited 2014 Aug 22];23(5):857–64. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24599578
Adamsen L, Quist M, Andersen C, Møller T, Herrstedt J, Kronborg D, et al. Effect of a multimodal high intensity exercise intervention in cancer patients undergoing chemotherapy: randomised controlled trial. BMJ [Internet]. 2009 Jan [cited 2014 Aug 18];339:b3410. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2762035&tool=pmcentrez&rendertype=abstract
Kortianou E a, Nasis IG, Spetsioti ST, Daskalakis AM, Vogiatzis I. Effectiveness of Interval Exercise Training in Patients with COPD. Cardiopulm Phys Ther J [Internet]. 2010 Sep;21(3):12–9. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2941353&tool=pmcentrez&rendertype=abstract
Bartlett JD, Close GL, MacLaren DPM, Gregson W, Drust B, Morton JP. High-intensity interval running is perceived to be more enjoyable than moderate-intensity continuous exercise: implications for exercise adherence. J Sports Sci. 2011;29:547–53.
Weston KS, Wisloff U, Coombes JS. High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: a systematic review and meta-analysis. Br J Sports Med [Internet]. 2014;48(16):1227–34. Available from: http://bjsm.bmj.com/cgi/doi/10.1136/bjsports-2013-092576
Beauchamp MK, Nonoyama M, Goldstein RS, Hill K, Dolmage TE, Mathur S, et al. Interval versus continuous training individuals with chronic obstructive pulmonary disease- a systematic review. Thorax [Internet]. 2010;65(2):157–64. Available from: http://thorax.bmj.com/cgi/doi/10.1136/thx.2009.123000
Alahmadi M. High-intensity Interval Training and Obesity. J Nov Physiother [Internet]. 2014;04(03). Available from: http://www.omicsgroup.org/journals/highintensity-interval-training-and-obesity-2165-7025-211.php?aid=28501
Wisloff U, Stoylen a., Loennechen JP, Bruvold M, Rognmo O, Haram PM, et al. Superior Cardiovascular Effect of Aerobic Interval Training Versus Moderate Continuous Training in Heart Failure Patients: A Randomized Study. Circulation [Internet]. 2007;115(24):3086–94. Available from: http://circ.ahajournals.org/cgi/doi/10.1161/CIRCULATIONAHA.106.675041
Nytrøen K, Rustad L a., Aukrust P, Ueland T, Hallén J, Holm I, et al. High-Intensity Interval Training Improves Peak Oxygen Uptake and Muscular Exercise Capacity in Heart Transplant Recipients. Am J Transplant [Internet]. 2012;12(11):3134–42. Available from: http://doi.wiley.com/10.1111/j.1600-6143.2012.04221.x
Devin JL, Sax AT, Hughes GI, Jenkins DG, Aitken JF, Chambers SK, et al. The influence of high-intensity compared with moderate-intensity exercise training on cardiorespiratory fitness and body composition in colorectal cancer survivors : a randomised controlled trial. J Cancer Surviv. 2015.
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